BISOPROLOL; HYDROCHLOROTHIAZIDE is a combination of a beta-blocker and a diuretic. It is used to treat high blood pressure.

They need to know if you have any of these conditions:

• circulation problems, or blood vessel disease
• decreased urine
• diabetes
• heart disease, heart failure or a history of heart attack
• kidney disease
• liver disease
• lung or breathing disease, like asthma
• slow heart rate
• thyroid disease
• an unusual or allergic reaction to hydrochlorothiazide, bisoprolol, sulfa drugs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

• barbiturates, like phenobarbital
• cholestyramine
• colestipol
• corticosteroids, like prednisone
• lithium
• medicines for chest pain or angina
• medicines for diabetes
• medicines for high blood pressure or heart failure
• medicines to control heart rhythm
• NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
• prescription pain medicines
• rifampin
• skeletal muscle relaxants like tubocurarine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.

Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

This medicine may affect your blood sugar level. If you have diabetes, check with your doctor or health care professional before changing the dose of your diabetic medicine.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• breathing problems
• chest pain
• cold, tingling, or numb hands or feet
• increased thirst or sweating
• fast, irregular, or slow heartbeat
• muscle cramps
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• swollen legs or ankles
• tremors
• unusual bruising
• unusual weak or tired
• vomiting
• worsened gout pain
• yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• change in sex drive or performance
• cough
• depression
• diarrhea
• nausea

This list may not describe all possible side effects.

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.