GLIMEPIRIDE; ROSIGLITAZONE is a combination medicine used to treat type 2 diabetes mellitus. Drug therapy for diabetes should be combined with a balanced diet, weight loss, and exercise. This medicine lowers blood sugar and helps your body use insulin more efficiently.

They need to know if you have any of these conditions:

• anemia
• heart problems such as heart attack or heart failure
• history of diabetic ketoacidosis
• hormone changes or problems
• kidney or liver problems
• major surgery
• polycystic ovaries
• serious infection or injury
• swelling of the arms, legs, or feet; water retention
• thyroid disease
• use insulin
• an unusual or allergic reaction to glimepiride, sulfonamides, rosiglitazone, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

Take glimepiride; rosiglitazone tablets by mouth, with the first meal of the day. Swallow the tablets with a drink of water. Take your dose at the same time each day. Do not take more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it with your next meal. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

• aspirin and aspirin-like medicines
• bosentan
• chloramphenicol
• diuretics
• female hormones, like estrogens and birth control pills
• gemfibrozil
• glyburide
• insulin
• isoniazid
• MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
• medicines for cold or congestion
• medicines for high blood pressure like metoprolol, propanolol
• medications for weight loss
• methotrexate
• miconazole
• NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
• phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
• phenytoin
• rifampin
• steroid medicines like prednisone or cortisone
• thyroid hormones

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

Visit your doctor or health care professional for regular checks on your progress. Learn how to check your blood sugar. Tell your doctor or health care professional if your blood sugar is high, you might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine. Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. If you have symptoms of low blood sugar, eat or drink something containing sugar at once and contact your doctor or health care professional. Make sure family members know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, like seizures or unconsciousness. They must get medical help at once.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• breathing problems
• changes in vision
• dark urine
• fever, chills, sore throat
• feeling faint or lightheaded, falls
• high blood pressure
• low blood sugar (ask your doctor or healthcare professional for a list of these symptoms)
• muscle aches, pains
• stomach pain
• swelling of the hands, legs, or feet
• unusually weak or tired
• yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• diarrhea
• headache
• loss of appetite
• nausea
• weight gain

This list may not describe all possible side effects.

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). protect form light and moisture. Throw away any unused medicine after the expiration date.