GLIMEPIRIDE helps to treat type 2 diabetes. Treatment is combined with diet and exercise. This medicine helps your body use insulin better.

They need to know if you have any of these conditions:

• diabetic ketoacidosis
• heart disease
• kidney disease
• liver disease
• severe infection or injury
• thyroid disease
• an unusual or allergic reaction to glimepiride, sulfa drugs, other medicines, foods, dyes, or preservatives
• pregnancy or recent attempts to get pregnant
• breast-feeding

Take this medicine by mouth. Swallow with a drink of water. Take your dose at the same time each day, with breakfast or your first large meal. Do not take more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Elderly patients over 65 years old can have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

• bosentan
• chloramphenicol
• cisapride
• medicines for fungal or yeast infections
• metoclopramide
• probenecid
• warfarin

Many medications may cause an increase or decrease in blood sugar, these include:

• alcohol containing beverages
• aspirin and aspirin-like drugs
• chloramphenicol
• chromium
• female hormones, like estrogens or progestins and birth control pills
• heart medicines
• isoniazid
• male hormones or anabolic steroids
• medicines for weight loss
• medicines for allergies, asthma, cold, or cough
• medicines for mental problems
• medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
• niacin
• NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
• pentamidine
• phenytoin
• probenecid
• quinolone antibiotics like ciprofloxacin, levofloxacin, ofloxacin
• some herbal dietary supplements
• steroid medicines like prednisone or cortisone
• thyroid medicine
• water pills or diuretics

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your doctor or health care professional for regular checks on your progress. Learn how to check your blood sugar. Tell your doctor or health care professional if your blood sugar is high, you might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine. Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. If you have symptoms of low blood sugar, eat or drink something containing sugar at once and contact your doctor or health care professional. Make sure family members know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, like seizures or unconsciousness. They must get medical help at once.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.

Side effects that you should report to your doctor or health care professional as soon as possible:

• breathing difficulties
• dark yellow or brown urine or yellowing of the eyes or skin
• fever, chills, sore throat
• low blood sugar (ask your doctor or healthcare professional for a list of these symptoms)
• severe skin rash, redness, swelling, or itching
• unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• diarrhea
• headache
• heartburn
• nausea, vomiting
• stomach discomfort

This list may not describe all possible side effects.

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date.